LMPD Database

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LMP005002

UniProt Annotations

Entry Information
Gene Namefatty acyl CoA reductase 1
Protein EntryFACR1_MOUSE
UniProt IDQ922J9
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q922J9-1; Sequence=Displayed; Name=2; IsoId=Q922J9-2; Sequence=VSP_021678, VSP_021679; Name=3; IsoId=Q922J9-3; Sequence=VSP_021680; Note=No experimental confirmation available.; Name=4; IsoId=Q922J9-4; Sequence=VSP_021681; Note=No experimental confirmation available.;
Biophysicochemical PropertiespH dependence: Optimum pH is 7.4. {ECO:0000269|PubMed:15220348};
Catalytic ActivityHexadecanal + CoA + NADP(+) = hexadecanoyl-CoA + NADPH.
FunctionCatalyzes the reduction of saturated fatty acyl-CoA with chain length C16 or C18 to fatty alcohols. {ECO:0000269|PubMed:15220348, ECO:0000269|PubMed:15220349}.
SimilarityBelongs to the fatty acyl-CoA reductase family. {ECO:0000305}.
Subcellular LocationPeroxisome membrane {ECO:0000305}; Single- pass membrane protein {ECO:0000305}.
SubunitInteracts (via C-terminus) with PEX19, the interaction is required for targeting to peroxisomes. {ECO:0000250|UniProtKB:Q8WVX9}.
Tissue SpecificityWidely expressed. Expressed in all tissues examined. Highest expression seen in preputial gland. Expressed in the brain where large quantities of ether lipids are synthesized. {ECO:0000269|PubMed:15220348}.