LMPD Database

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LMP004990

UniProt Annotations

Entry Information
Gene Namephosphatidic acid phosphatase type 2 domain containing 3
Protein EntryPPAC3_MOUSE
UniProt IDQ91WB2
SpeciesMouse
Comments
Comment typeDescription
FunctionPlays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity. Knockdown in myoblasts strongly promotes differentiation, whereas overexpression represses myogenesis. {ECO:0000269|PubMed:19704009}.
InductionUp-regulated during myoblast differentiation. {ECO:0000269|PubMed:17062158, ECO:0000269|PubMed:19704009}.
SimilarityBelongs to the PA-phosphatase related phosphoesterase family. {ECO:0000305}.
Subcellular LocationNucleus envelope. Endoplasmic reticulum membrane. Membrane; Multi-pass membrane protein. Note=Both the N- and C-terminal are exposed to the cytoplasm/nucleoplasm.
SubunitHomo- and heterooligomer. Interacts with MTOR; controls MTOR-dependent IGF2 expression during myoblast differentiation. {ECO:0000269|PubMed:19704009}.
Tissue SpecificityHighly expressed in heart and muscle. {ECO:0000269|PubMed:17062158, ECO:0000269|PubMed:19704009}.