LMPD Database

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LMP004923

UniProt Annotations

Entry Information
Gene Namesteroid 5 alpha-reductase 3
Protein EntryPORED_MOUSE
UniProt IDQ9WUP4
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9WUP4-1; Sequence=Displayed; Name=2; IsoId=Q9WUP4-2; Sequence=VSP_039779; Note=No experimental confirmation available.;
Catalytic ActivityA 3-oxo-5-alpha-steroid + NADP(+) = a 3-oxo- Delta(4)-steroid + NADPH.
Catalytic ActivityDitrans,polycis-dolichol + NADP(+) = ditrans,polycis-polyprenol + NADPH.
Disruption PhenotypeDeath by E12.5. At E10.5, embryos are smaller and fail to undergo axial rotation observed at E8.5 in wild-types and present dilated hearts and open neural tubes. {ECO:0000269|PubMed:20637498}.
FunctionPlays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT). {ECO:0000269|PubMed:20637498}.
PathwayProtein modification; protein glycosylation. {ECO:0000269|PubMed:20637498}.
SimilarityBelongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.