LMPD Database

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LMP004896

UniProt Annotations

Entry Information
Gene Nameformyl peptide receptor 3
Protein EntryFPRS1_MOUSE
UniProt IDO08790
SpeciesMouse
Comments
Comment typeDescription
FunctionLow affinity receptor for N-formyl-methionyl peptides. Receptor for lipoxin A4. May have an olfactory function associated with the identification of pathogens or of pathogenic states. {ECO:0000269|PubMed:19387439}.
SimilarityBelongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.
Subcellular LocationCell membrane; Multi-pass membrane protein.
Tissue SpecificityExpressed exclusively in vomeronasal neurons (PubMed:19387439 and PubMed:19497865). Expressed in 0.6 % of a subset of sensory neurons located in the basal layer of the vomeronasal organ. Each neuron appears to express only one receptor gene. Expressed mostly in neutrophils, followed by spleen and lung and expressed at very low levels in heart and liver (PubMed:19387439). {ECO:0000269|PubMed:19387439, ECO:0000269|PubMed:19497865, ECO:0000269|PubMed:9151906, ECO:0000269|PubMed:9722950}.
Web ResourceName=Protein Spotlight; Note=A sickly smell - Issue 114 of February 2010; URL="http://web.expasy.org/spotlight/back_issues/114";