LMPD Database

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LMP004875

UniProt Annotations

Entry Information
Gene NameATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
Protein EntryVATL_HUMAN
UniProt IDP27449
SpeciesHuman
Comments
Comment typeDescription
FunctionProton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
InteractionQ96G23:CERS2; NbExp=3; IntAct=EBI-721179, EBI-1057080; P0CK45:E5 (xeno); NbExp=2; IntAct=EBI-721179, EBI-7015490;
PtmUbiquitinated by RNF182, leading to its degradation via the ubiquitin-proteasome pathway.
SimilarityBelongs to the V-ATPase proteolipid subunit family.
Subcellular LocationVacuole membrane; Multi-pass membrane protein.
SubunitV-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (main components: subunits A, B, C, D, E, and F) attached to an integral membrane V0 proton pore complex (main component: the proteolipid protein; which is present as a hexamer that forms the proton-conducting pore). Interacts with LASS2. Interacts with HTLV-1 accessory protein p12I. Interacts with RNF182; this interaction leads to ubiquitination and degradation via the proteasome pathway. {ECO