LMPD Database

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LMP004810

UniProt Annotations

Entry Information
Gene Namedolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
Protein EntryDPM1_HUMAN
UniProt IDO60762
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityGDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate.
DiseaseCongenital disorder of glycosylation 1E (CDG1E) [MIM
FunctionTransfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O- mannosylation of proteins; catalytic subunit of the dolichol- phosphate mannose (DPM) synthase complex.
InteractionQ9P2X0:DPM3; NbExp=4; IntAct=EBI-719526, EBI-9087337;
PathwayProtein modification; protein glycosylation.
SimilarityBelongs to the glycosyltransferase 2 family.
Subcellular LocationEndoplasmic reticulum.
SubunitComponent of the dolichol-phosphate mannose (DPM) synthase complex composed of DPM1, DPM2 and DPM3; in the complex interacts directly with DPM3. {ECO
Web ResourceName=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=DPM1";