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LMPD Database

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LMP004802

UniProt Annotations

Entry Information

Gene Name	phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 4, p150
Protein Entry	PI3R4_MOUSE
UniProt ID	Q8VD65
Species	Mouse

Comments

Comment type	Description
Catalytic Activity	ATP + a protein = ADP + a phosphoprotein.
Cofactor	Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
Function	Regulatory subunit of the PI3K complex. May regulate membrane trafficking late in the endocytic pathway (By similarity). {ECO:0000250}.
Ptm	Myristoylated. {ECO:0000250}.
Ptm	Probably autophosphorylated. {ECO:0000250}.
Similarity	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. {ECO:0000255\|PROSITE-ProRule:PRU00159}.
Similarity	Contains 1 protein kinase domain. {ECO:0000255\|PROSITE-ProRule:PRU00159}.
Similarity	Contains 4 HEAT repeats. {ECO:0000255\|PROSITE- ProRule:PRU00103}.
Similarity	Contains 7 WD repeats. {ECO:0000255\|PROSITE- ProRule:PRU00221}.
Subcellular Location	Late endosome {ECO:0000250}. Note=Localizes also to discrete punctae along the ciliary axoneme. {ECO:0000269\|PubMed:24089209}.
Subunit	Heterodimer. This subunit, part of a complex composed of regulatory and catalytic subunits, associates with the phosphatidylinositol 3-kinase type 3 (PIK3C3) (By similarity). Forms a complex with BECN1, PIK3C3 and either UVRAG and KIAA0226/Rubicon, or with ATG14. In this complex, presence of UVRAG and ATG14 are mutually exclusive (By similarity). Part of a complex composed by PIK3C3 and PIK3CB. Interacts with RAB7A in the presence of PIK3C3/VPS34 (By similarity). {ECO:0000250}.