LMPD Database

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LMP004801

UniProt Annotations

Entry Information
Gene Namelipase, hormone sensitive
Protein EntryLIPS_MOUSE
UniProt IDP54310
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P54310-1; Sequence=Displayed; Name=2; IsoId=P54310-2; Sequence=VSP_053335;
Catalytic ActivityDiacylglycerol + H(2)O = monoacylglycerol + a carboxylate.
Catalytic ActivityMonoacylglycerol + H(2)O = glycerol + a carboxylate.
Catalytic ActivityTriacylglycerol + H(2)O = diacylglycerol + a carboxylate.
Enzyme RegulationRapidly activated by cAMP-dependent phosphorylation under the influence of catecholamines. Dephosphorylation and inactivation are controlled by insulin (By similarity). Interacts with PLIN5. {ECO:0000250}.
FunctionIn adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production. {ECO:0000269|PubMed:23291629}.
PathwayGlycerolipid metabolism; triacylglycerol degradation.
PtmPhosphorylation by AMPK may block translocation to lipid droplets. {ECO:0000269|PubMed:15878856, ECO:0000269|PubMed:19921680}.
SimilarityBelongs to the 'GDXG' lipolytic enzyme family. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000250}. Membrane, caveola {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Note=Found in the high-density caveolae. Translocates to the cytoplasm from the caveolae upon insulin stimulation. {ECO:0000250}.
SubunitInteracts with PTRF in the adipocyte cytoplasm. {ECO:0000250}.