LMPD Database

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LMP004786

UniProt Annotations

Entry Information
Gene Namecytochrome P450, family 2, subfamily R, polypeptide 1
Protein EntryCP2R1_HUMAN
UniProt IDQ6VVX0
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=0.67 uM for vitamin D(2) {ECO
Catalytic ActivityCalciol + O(2) + NADPH = calcidiol + NADP(+) H(2)O. {ECO
CofactorName=heme; Xref=ChEBI
DiseaseRickets vitamin D-dependent 1B (VDDR1B) [MIM
FunctionHas a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3). {ECO
SimilarityBelongs to the cytochrome P450 family.
Subcellular LocationEndoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
SubunitHomodimer.