LMPD Database

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LMP004765

UniProt Annotations

Entry Information
Gene Namephosphatidylinositol-4-phosphate 5-kinase, type I, beta
Protein EntryPI51B_HUMAN
UniProt IDO14986
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=O14986-1; Sequence=Displayed; Name=2; Synonyms=Isoform 1; IsoId=O14986-2; Sequence=VSP_016010, VSP_016011; Name=3; IsoId=O14986-3; Sequence=VSP_054771; Note=No experimental confirmation available.;
Catalytic ActivityATP + 1-phosphatidyl-1D-myo-inositol 4- phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
CautionThere is confusion in the literature with phosphatidylinositol 4-phosphate 5-kinase type I nomenclature due to the fact that frequently mouse PIP5K1B is named Phosphatidylinositol 4-phosphate 5-kinase type I alpha.
FunctionParticipates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of PLD2. Together with PIP5K1A is required after stimulation of G-protein coupled receptors for stable platelet adhesion (By similarity).
SimilarityContains 1 PIPK domain. {ECO
Subcellular LocationEndomembrane system . Note=Associated with membranes.
SubunitInteracts with RAC1, AJUBA, PLD1, PLD2 and ARF1.
Tissue SpecificityDetected in heart, pancreas, brain, kidney, skeletal muscle and lung.