LMPD Database

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LMP004721

UniProt Annotations

Entry Information
Gene NameDnaJ (Hsp40) homolog, subfamily A, member 1
Protein EntryDNJA1_MOUSE
UniProt IDP63037
SpeciesMouse
Comments
Comment typeDescription
FunctionCo-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity). Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. {ECO:0000250, ECO:0000269|PubMed:14752510}.
SimilarityContains 1 CR-type zinc finger. {ECO:0000305}.
SimilarityContains 1 J domain. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Cytoplasm {ECO:0000250}. Microsome {ECO:0000250}. Mitochondrion {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Note=Primarily cytoplasmic and associated with microsomes. A minor proportion is associated with nuclei and mitochondria (By similarity). {ECO:0000250}.
SubunitIdentified in a complex with HSPA1B and BAX. {ECO:0000269|PubMed:14752510}.