LMPD Database

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LMP004709

UniProt Annotations

Entry Information
Gene Namecarboxylesterase 1D
Protein EntryQ8VCT4_MOUSE
UniProt IDQ8VCT4
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityA carboxylic ester + H(2)O = an alcohol + a carboxylate. {ECO:0000255|PROSITE-ProRule:PRU10039, ECO:0000269|PubMed:15269189}.
Catalytic ActivityA long-chain-fatty-acyl ethyl ester + H(2)O = a long-chain-fatty acid + ethanol.
CautionWas originally thought to originate from human.
FunctionMajor lipase in white adipose tissue. Involved in the metabolism of xenobiotics and of natural substrates. Hydrolyzes triacylglycerols and monoacylglycerols, with a preference for monoacylglycerols. The susceptibility of the substrate increases with decreasing acyl chain length of the fatty acid moiety. Catalyzes the synthesis of fatty acid ethyl esters.
InductionBy di-(2-ethylhexyl) phthalate.
SimilarityBelongs to the type-B carboxylesterase/lipase family.
Subcellular LocationEndoplasmic reticulum lumen . Cytoplasm, cytosol . Lipid droplet .
SubunitHomotrimer.
Tissue SpecificityHighest expression occurs in liver with lower levels in adipose tissue, kidney, heart, intestine, lung, testis and thymus. {ECO:0000269|PubMed:11470237, ECO:0000269|PubMed:15269189}.