LMPD Database

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LMP004702

UniProt Annotations

Entry Information
Gene Namecollagen, type IV, alpha 3 (Goodpasture antigen) binding protein
Protein EntryC43BP_MOUSE
UniProt IDQ9EQG9
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9EQG9-1; Sequence=Displayed; Name=2; Synonyms=Delta26, GPBPD26; IsoId=Q9EQG9-2; Sequence=VSP_006277; Name=3; IsoId=Q9EQG9-3; Sequence=VSP_028735, VSP_028736; Note=No experimental confirmation available.;
DomainThe FFAT motif is required for interaction with VAPA and VAPB. {ECO:0000250}.
DomainThe PH domain targets the Golgi apparatus. {ECO:0000250}.
DomainThe START domain recognizes ceramides and diacylglycerol lipids, interacts with membranes, and mediates the intermembrane transfer of ceramides and diacylglycerol lipids. {ECO:0000250}.
FunctionShelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner. {ECO:0000250}.
PtmPhosphorylation on Ser-132 decreases the affinity toward phosphatidylinositol 4-phosphate at Golgi membranes and reduces ceramide transfer activity. Inactivated by hyperphosphorylation of serine residues by CSNK1G2/CK1 that triggers dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis (By similarity). {ECO:0000250}.
Sequence CautionSequence=AAH16197.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};
SimilarityContains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
SimilarityContains 1 START domain. {ECO:0000255|PROSITE- ProRule:PRU00197}.
Subcellular LocationCytoplasm {ECO:0000250}. Golgi apparatus {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Note=Preferentially localized to the Golgi apparatus. {ECO:0000250}.
SubunitInteracts with VAPA and VAPB. Interaction with VAPB is less efficient than with VAPA (By similarity). Interacts with COL4A3. {ECO:0000250}.