LMPD Database

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LMP004667

UniProt Annotations

Entry Information
Gene NameRas-related GTP binding C
Protein EntryQ99K70_MOUSE
UniProt IDQ99K70
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1 ; IsoId=Q99K70-1; Sequence=Displayed; Name=2 ; IsoId=Q99K70-2; Sequence=VSP_052076, VSP_052077; Note=No experimental confirmation available. ;
FunctionGuanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids (By similarity).
Sequence CautionSequence=BAA75671.1; Type=Frameshift; Positions=19, 56, 68, 71; Evidence= ;
SimilarityBelongs to the GTR/RAG GTP-binding protein family.
Subcellular LocationCytoplasm . Nucleus {ECO:0000250}. Lysosome . Note=Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state of associated RRAGA (By similarity).
SubunitForms a heterodimer with RRAGA, in a sequence-independent manner, and RRAGB. Heterodimerization stabilizes proteins of the heterodimer. In complex with RRAGA or RRAGB, interacts with RPTOR; this interaction is particularly efficient with GTP-loaded RRAGB and GDP-loaded RRAGC. Interacts with NOL8. Interacts with SH3BP4; the interaction with this negative regulator is most probably direct, preferentially occurs with the inactive GDP-bound form of RRAGB, is negatively regulated by amino acids and prevents interaction with RPTOR (By similarity).
Tissue SpecificityExpressed most abundantly in kidney. Moderately expressed in brain, ovary, and testis, and detected at lower levels in heart, liver, and muscle. Not detected in lung, spleen, and small intestine. Widely expressed in tumor cells, with expression being specifically up-regulated in highly metastatic cells.