LMPD Database

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LMP004662

UniProt Annotations

Entry Information
Gene Namearylacetamide deacetylase
Protein EntryAAAD_HUMAN
UniProt IDP22760
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=0.8 mM for flutamide {ECO
Catalytic ActivityTriacylglycerol + H(2)O = diacylglycerol + a carboxylate.
FunctionDisplays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity. {ECO
InductionDown-regulated following infection with hepatis C virus which results in impaired triacylglycerol lipolysis and impaired assembly of very low density lipoproteins. This may represent a cellular adaptation to infection that is aimed at limiting viral production.
MiscellaneousCan hydrolyze a number of clinical drugs such as flutamide, an antiandrogen drug used for the treatment of prostate cancer; phenacetin, an analgesic antipyretic which has been withdrawn from the market due to its links with renal failure; and rifamycins which have been used as antituberculosis drugs.
PolymorphismThree alleles are known: AADAC*1, AADAC*2 and AADAC*3. The sequence shown is that of AADAC*1 which is found in European American, African American, Japanese and Korean populations at allelic frequencies of 39.3 to 47.4%. The AADAC*2 allele is found in European American, African American, Korean, and Japanese populations at allelic frequencies of 52.6 to 63.5% whereas the AADAC*3 allele is found in European American (1.3%) and African American (2.0%) samples but not in Japanese or Korean samples.
PtmGlycosylation is required for enzyme activity.
Sequence CautionSequence=AAA35551.1; Type=Frameshift; Positions=53, 56; Evidence= ;
SimilarityBelongs to the 'GDXG' lipolytic enzyme family.
Subcellular LocationEndoplasmic reticulum membrane; Single-pass type II membrane protein. Microsome membrane; Single-pass type II membrane protein.
Tissue SpecificityDetected in liver (at protein level). Mainly expressed in liver, small intestine, colon, adrenal gland and bladder. {ECO