LMPD Database

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LMP004657

UniProt Annotations

Entry Information
Gene Nametubulointerstitial nephritis antigen-like 1
Protein EntryTINAL_HUMAN
UniProt IDQ9GZM7
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9GZM7-1; Sequence=Displayed; Name=2; IsoId=Q9GZM7-2; Sequence=VSP_013094, VSP_013095, VSP_013096, VSP_013097, VSP_013098; Name=3; IsoId=Q9GZM7-3; Sequence=VSP_043712; Note=No experimental confirmation available.;
FunctionMay be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells. This is a non catalytic peptidase C1 family protein (By similarity).
PtmGlycosylated. {ECO
Sequence CautionSequence=AAH09048.1; Type=Erroneous initiation; Evidence= ; Sequence=BAB55403.1; Type=Erroneous initiation; Evidence= ;
SimilarityBelongs to the peptidase C1 family.
SimilarityContains 1 SMB (somatomedin-B) domain.
Subcellular LocationSecreted {ECO
Tissue SpecificityHighly expressed in aorta, heart, placenta, kidney and a colorectal adenocarcinoma cell line. Moderately expressed in skeletal muscle, pancreas, lung, lymph nodes, adrenal gland, bone marrow and thyroid. Weakly expressed in colon, small intestine, ovary, spleen, testis and prostate. Predominantly found in vascular smooth muscle cells, but also in cardiac and skeletal muscle cells as well as kidney.