LMPD Database

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LMP004586

UniProt Annotations

Entry Information
Gene Nameglutathione peroxidase 7
Protein EntryGPX7_HUMAN
UniProt IDQ96SL4
SpeciesHuman
Comments
Comment typeDescription
Catalytic Activity2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.
DiseaseBarrett esophagus (BE) [MIM
FunctionIt protects esophageal epithelia from hydrogen peroxide- induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks.
Sequence CautionSequence=AAC72961.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence= ;
SimilarityBelongs to the glutathione peroxidase family.
Subcellular LocationSecreted .
Tissue SpecificityExpressed in esophageal epithelial cells; expression is up-regulated after exposure to acidic bile acids.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/gpx7/";