LMPD Database

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LMP004582

UniProt Annotations

Entry Information
Gene Namelow density lipoprotein receptor class A domain containing 3
Protein EntryLRAD3_HUMAN
UniProt IDQ86YD5
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q86YD5-1; Sequence=Displayed; Name=2; IsoId=Q86YD5-2; Sequence=VSP_056254;
FunctionMay influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production.
SimilarityBelongs to the LDLR family.
SimilarityContains 3 LDL-receptor class A domains.
Subcellular LocationCell membrane ; Single-pass type I membrane protein .
SubunitInteracts with APP precursor C-terminus.
Tissue SpecificityExpressed at high levels in brain, lung, skeletal muscle, and pancreas. Expressed at moderate levels in heart, placenta, and kidney but not detected in the liver.