LMPD Database

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LMP004575

UniProt Annotations

Entry Information
Gene Namegloboside alpha-1,3-N-acetylgalactosaminyltransferase 1
Protein EntryGBGT1_HUMAN
UniProt IDQ8N5D6
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8N5D6-1; Sequence=Displayed; Name=2; IsoId=Q8N5D6-2; Sequence=VSP_013750; Note=No experimental confirmation available.; Name=3; IsoId=Q8N5D6-3; Sequence=VSP_055375; Note=No experimental confirmation available.;
CautionIn contrast to its mouse or canine ortholog, it does not mediate the formation of Forssman glycolipid (also called Forssman antigen; FG), which does not exist in human. It is unknown whether it has no enzyme activity at all or has some distinct substrate specificity compared to the canine and mouse protein.
CofactorName=Mn(2+); Xref=ChEBI
DomainThe conserved DXD motif is involved in cofactor binding. The manganese ion interacts with the beta-phosphate group of UDP and may also have a role in catalysis (By similarity).
FunctionCatalyzes the formation of some glycolipid via the addition of N-acetylgalactosamine (GalNAc) in alpha-1,3-linkage to some substrate. Glycolipids probably serve for adherence of some pathogens.
PathwayProtein modification; protein glycosylation.
SimilarityBelongs to the glycosyltransferase 6 family.
Subcellular LocationGolgi apparatus membrane ; Single-pass type II membrane protein .
Tissue SpecificityWidely expressed. Expressed at higher level in placenta, ovary and peripheral blood leukocyte, whereas it is weakly expressed in liver, thymus, and testis.
Web ResourceName=Functional Glycomics Gateway - GTase; Note=Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_479";
Web ResourceName=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=GBGT1";
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/gbgt1/";