LMPD Database

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LMP004550

UniProt Annotations

Entry Information
Gene Namedolichol-phosphate (beta-D) mannosyltransferase 1
Protein EntryDPM1_MOUSE
UniProt IDO70152
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityGDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate.
FunctionTransfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O- mannosylation of proteins; catalytic subunit of the dolichol- phosphate mannose (DPM) synthase complex. {ECO:0000250}.
PathwayProtein modification; protein glycosylation.
SimilarityBelongs to the glycosyltransferase 2 family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum.
SubunitComponent of the dolichol-phosphate mannose (DPM) synthase complex composed of DPM1, DPM2 and DPM3; in the complex interacts directly with DPM3. {ECO:0000250}.