LMPD Database

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LMP004523

UniProt Annotations

Entry Information
Gene Nametubulointerstitial nephritis antigen-like 1
Protein EntryTINAL_MOUSE
UniProt IDQ99JR5
SpeciesMouse
Comments
Comment typeDescription
FunctionMay be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells. This is a non catalytic peptidase C1 family protein. {ECO:0000269|PubMed:12600995}.
InductionDown-regulated in prostate after castration. {ECO:0000269|PubMed:11377975}.
PtmGlycosylated. {ECO:0000250}.
Sequence CautionSequence=BAB20596.1; Type=Frameshift; Positions=43; Evidence={ECO:0000305};
SimilarityBelongs to the peptidase C1 family. {ECO:0000255|PROSITE-ProRule:PRU10089}.
SimilarityContains 1 SMB (somatomedin-B) domain. {ECO:0000305}.
Subcellular LocationSecreted.
Tissue SpecificityHighly expressed in kidney, heart and adrenocortical cells of adrenal glands. Moderately expressed in spleen and liver. Also found in prostate, seminal vesicle, epididymis and testis in male reproductive organs. In adrenal glands is found in the outer cortical regions corresponding to the zona glomerulosa (zG) and the undifferentiated cell zone (zU) (at protein level). {ECO:0000269|PubMed:11377975, ECO:0000269|PubMed:12600995}.