LMPD Database

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LMP004491

UniProt Annotations

Entry Information
Gene Nameabhydrolase domain containing 4
Protein EntryABHD4_HUMAN
UniProt IDQ8TB40
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8TB40-1; Sequence=Displayed; Name=2; IsoId=Q8TB40-2; Sequence=VSP_056924, VSP_056925; Note=No experimental confirmation available;
CautionThr-291 is present instead of the conserved His which is expected to be an active site residue.
FunctionLysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine (By similarity).
SimilarityBelongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.