Skip to main content

LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins

LMP004430

UniProt Annotations

Entry Information

Gene Name	nuclear receptor interacting protein 1
Protein Entry	Q8CBD1_MOUSE
UniProt ID	Q8CBD1
Species	Mouse

Comments

Comment type	Description
Domain	Contains 9 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, which have different affinities for nuclear receptors.
Domain	Contains at least 4 autonomous repression domains (RD1-4).
Domain	The Ligand-dependent nuclear receptor binding region is required for ligand-dependent interaction with RAAR and RXRB homo- and heterodimers, for the corepressor activity, and for the formation of an HDAC3 complex with RARA/RXRB.
Function	Modulates transcriptional repression by nuclear hormone receptors such as NR2C1, thyroid hormone receptor and retinoic acid receptor/RARA. Essential for cumulus expansion and follicle rupture during ovulation. Also controls the balance between fat accumulation and energy expenditure. Positive regulator of the circadian clock gene expression: stimulates transcription of ARNTL/BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. {ECO:0000269\|PubMed:10531331, ECO:0000269\|PubMed:11100122, ECO:0000269\|PubMed:15130509, ECO:0000269\|PubMed:15155905, ECO:0000269\|PubMed:15919748, ECO:0000269\|PubMed:21628546, ECO:0000269\|PubMed:9774688}.
Interaction	O15379:HDAC3 (xeno); NbExp=2; IntAct=EBI-1771626, EBI-607682;
Ptm	Acetylation abolishes interaction with CTBP1. Phosphorylation enhances interaction with YWHAH (By similarity). Acetylation regulates its nuclear translocation and corepressive activity. {ECO:0000250\|UniProtKB:P48552, ECO:0000269\|PubMed:15846843, ECO:0000269\|PubMed:15879431}.
Subcellular Location	Nucleus .
Subunit	Interacts with CTBP1, CTBP2, ERS1, HDAC1, HDAC2, HDAC5, HDAC6, NR2C2, NR3C1, NR3C2, YWHAH, JUN and FOS. Found in a complex with both NR3C1 and YWHAH (By similarity). Interacts with NR2C1 (sumoylated form and via the ligand-binding domain); the interaction results in promoting the repressor activity of NR2C1. Interacts with RARA and RXRB homodimers and RARA/RXRB heterodimers in the presence of ligand. Interacts with HDAC1 and HDAC3 via its N-terminal domain. Interacts with ZNF366 (By similarity). Interacts with RORA. {ECO:0000250\|UniProtKB:P48552, ECO:0000269\|PubMed:21628546}.
Tissue Specificity	Expressed in the embryonic placenta. In the adult, expression is strong in the testis and brain. Also expressed at a high level in the white adipose tissue. Expressed constantly but at a weaker level in the adult heart, lung, stomach and kidney. Expressed moderately in the skeletal muscle. Expressed at a low level in the adult spleen, liver and brown adipose tissue. Expressed in the ovary at a high level in granulosa cells and at a lower level in the thecal and interstitial compartments. {ECO:0000269\|PubMed:11100122, ECO:0000269\|PubMed:15155905, ECO:0000269\|PubMed:9774688}.