LMPD Database

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LMP004429

UniProt Annotations

Entry Information
Gene Nameretinol dehydrogenase 10 (all-trans)
Protein EntryRDH10_MOUSE
UniProt IDQ8VCH7
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityAll-trans-retinol + NADP(+) = all-trans- retinal + NADPH.
Developmental StageFirst detected in the neural groove at E8.0. At E8.5, detected in lateral plate mesoderm, the dorsal region of the somites, the floor plate of the neural tube and in head mesenchyme. At E9.5, detected in dorsal paraxial mesoderm, lateral plate mesoderm and in nephrogenic cord tissues. At E10.5, detected in lung buds, developing mesonephros, mesodermal tissue surrounding dorsal root ganglia and adjacent to the forlimb buds. {ECO:0000269|PubMed:17473173}.
FunctionRetinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol (By similarity). Required for normal embryonic development. {ECO:0000250, ECO:0000269|PubMed:17473173}.
PathwayCofactor metabolism; retinol metabolism.
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.
Subcellular LocationMicrosome membrane {ECO:0000305}; Single- pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Tissue SpecificityDetected in retinal pigment epithelium (at protein level). {ECO:0000269|PubMed:12407145, ECO:0000269|PubMed:15505029}.