LMPD Database

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LMP004374

UniProt Annotations

Entry Information
Gene Nameubiquitin interaction motif containing 1
Protein EntryQ5U5Q9_MOUSE
UniProt IDQ5U5Q9
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5U5Q9-1; Sequence=Displayed; Name=2; IsoId=Q5U5Q9-2; Sequence=VSP_037267, VSP_037268; Note=No experimental confirmation available.; Name=3; IsoId=Q5U5Q9-3; Sequence=VSP_037266; Note=No experimental confirmation available.;
DomainThe Abraxas-interacting region (AIR) mediates the interaction with FAM175A/Abraxas. {ECO:0000250}.
DomainThe UIM-linker region between the 2 UIM repeats determines the selectivity for 'Lys-63'-linked ubiquitin. The length of the linker is important. The linker reduces the flexibility between the UIM repeats and promotes high-affinity and linkage-selective interactions (By similarity). {ECO:0000250}.
FunctionUbiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1 (By similarity). {ECO:0000250}.
InteractionP62991:Ubc; NbExp=2; IntAct=EBI-7068640, EBI-413074;
PtmPhosphorylated upon DNA damage by ATM or ATR. {ECO:0000250}.
PtmSumoylated. {ECO:0000250}.
Sequence CautionSequence=AAH37092.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the RAP80 family. {ECO:0000305}.
SimilarityContains 2 UIM (ubiquitin-interacting motif) repeats. {ECO:0000255|PROSITE-ProRule:PRU00213}.
Subcellular LocationNucleus {ECO:0000250}. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). {ECO:0000250}.
SubunitComponent of the BRCA1-A complex, at least composed of the BRCA1, BARD1, UIMC1/RAP80, FAM175A/Abraxas, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with FAM175A/Abraxas. Interacts with ESR1 and UBE2I (By similarity). Interacts with NR6A1 and TSP57. {ECO:0000250, ECO:0000269|PubMed:12954732, ECO:0000269|PubMed:7760852}.