LMPD Database

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LMP004347

UniProt Annotations

Entry Information
Gene NameS-adenosylhomocysteine hydrolase-like 1
Protein EntrySAHH2_MOUSE
UniProt IDQ80SW1
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityS-adenosyl-L-homocysteine + H(2)O = L- homocysteine + adenosine.
CofactorName=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence={ECO:0000250}; Note=Binds 1 NAD(+) per subunit. {ECO:0000250};
DomainThe PEST region is essential for the interaction with ITPR1. The PDZ-binding region is required for maximal interaction with ITPR1 and is also responsible for the IP3-insensitive interaction with ITPR1.
PathwayAmino-acid biosynthesis; L-homocysteine biosynthesis; L- homocysteine from S-adenosyl-L-homocysteine: step 1/1.
SimilarityBelongs to the adenosylhomocysteinase family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum {ECO:0000269|PubMed:16527252}.
SubunitInteracts with ITPR1. Competes with IP3 for interaction with ITPR1 and attenuates IP3-induced Ca(2+) release through the ITPR1 from the non-mitochondrial intracellular stores. {ECO:0000269|PubMed:12525476, ECO:0000269|PubMed:16527252}.