LMPD Database

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LMP004318

UniProt Annotations

Entry Information
Gene Namephospholipase A2 receptor 1, 180kDa
Protein EntryPLA2R_HUMAN
UniProt IDQ13018
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q13018-1; Sequence=Displayed; Name=2; IsoId=Q13018-2; Sequence=VSP_029493, VSP_029494;
DomainC-type lectin domains 3-5 mediate the interaction with phospholipase PLA2G1B.
DomainThe endocytosis signal probably mediates endocytosis via clathrin-coated pits.
FunctionReceptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2- IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2- IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow- derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B. {ECO
PtmThe secretory phospholipase A2 receptor form may be produced by the action of metalloproteinases. It contains all extracellular domains and only lacks transmembrane and cytosolic regions. It is however unclear whether this form is produced by proteolytic cleavage as suggested by some experiments, or by alternative splicing, as in the case of isoform 2 that shares all characteristics of secretory phospholipase A2 receptor form (By similarity).
SimilarityContains 1 fibronectin type-II domain.
SimilarityContains 1 ricin B-type lectin domain.
SimilarityContains 8 C-type lectin domains.
Subcellular LocationCell membrane ; Single-pass type I membrane protein .
Subcellular LocationIsoform 2: Secreted .
Subcellular LocationSoluble secretory phospholipase A2 receptor: Secreted .
Tissue SpecificityPresent in lung macrophage (at protein level). Highly expressed in kidney. Also expressed in pancreas, amnion, choriodecidua and placenta. Isoform 2 is expressed at much lower level. {ECO
Web ResourceName=Functional Glycomics Gateway - Glycan Binding; Note=Phospholipase A2 receptor; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_253";