LMPD Database

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LMP004304

UniProt Annotations

Entry Information
Gene Nameprotein disulfide isomerase associated 3
Protein EntryPDIA3_MOUSE
UniProt IDP27773
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityCatalyzes the rearrangement of -S-S- bonds in proteins.
CautionWas originally thought to be a phosphatidylinositol 4,5- bisphosphate phosphodiesterase type I (phospholipase C-alpha). {ECO:0000305|PubMed:2033248}.
PtmPhosphorylated. {ECO:0000269|Ref.7}.
SimilarityBelongs to the protein disulfide isomerase family. {ECO:0000305}.
SimilarityContains 2 thioredoxin domains. {ECO:0000255|PROSITE- ProRule:PRU00691}.
Subcellular LocationEndoplasmic reticulum {ECO:0000250}. Endoplasmic reticulum lumen {ECO:0000250}. Melanosome {ECO:0000250}.
SubunitSubunit of the TAP complex, also known as the peptide loading complex (PLC). Can form disulfide-linked heterodimers with TAPBP. Interacts with ERP27 and CANX (By similarity). Interacts with MZB1 in a calcium-dependent manner. Interacts with SERPINA2 and with the S and Z variants of SERPINA1 (By similarity). {ECO:0000250}.
Tissue SpecificityIn caput and cauda epididymal spermatozoa, detected in the acrosome and principal piece (at protein level). {ECO:0000269|PubMed:20400973}.