LMPD Database

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LMP004297

UniProt Annotations

Entry Information
Gene Namehydroxyprostaglandin dehydrogenase 15 (NAD)
Protein EntryPGDH_MOUSE
UniProt IDQ8VCC1
SpeciesMouse
Comments
Comment typeDescription
Catalytic Activity(5Z,13E,15S)-11-alpha,15-dihydroxy-9-oxoprost- 5,13-dienoate + NAD(+) = (5Z,13E)-11-alpha-hydroxy-9,15- dioxoprost-5,13-dienoate + NADH.
FunctionProstaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4 (By similarity). {ECO:0000250}.
Sequence CautionSequence=AAB41825.1; Type=Frameshift; Positions=267; Evidence={ECO:0000305};
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000250}.
SubunitHomodimer. {ECO:0000250}.
Tissue SpecificityExpressed in lung, intestine, stomach and liver. {ECO:0000269|PubMed:8950170}.