LMPD Database

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LMP004256

UniProt Annotations

Entry Information
Gene Name2,4-dienoyl CoA reductase 1, mitochondrial
Protein EntryDECR_HUMAN
UniProt IDQ16698
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q16698-1; Sequence=Displayed; Name=2; IsoId=Q16698-2; Sequence=VSP_056388; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=7.7 uM for NADPH ; KM=14.3 uM for trans-2,trans-4-hexadienoyl-CoA ; Vmax=30.3 umol/min/mg enzyme ;
Catalytic ActivityTrans-2,3-didehydroacyl-CoA + NADP(+) = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH.
FunctionAuxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3- enoyl-CoA.
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.
Subcellular LocationMitochondrion.
SubunitHomotetramer.
Tissue SpecificityHeart = liver = pancreas > kidney >> skeletal muscle = lung.