LMPD Database

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LMP004255

UniProt Annotations

Entry Information
Gene Namesuccinate-CoA ligase, alpha subunit
Protein EntrySUCA_HUMAN
UniProt IDP53597
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityATP + succinate + CoA = ADP + phosphate + succinyl-CoA.
Catalytic ActivityGTP + succinate + CoA = GDP + phosphate + succinyl-CoA.
DiseaseMitochondrial DNA depletion syndrome 9 (MTDPS9) [MIM
FunctionCatalyzes the ATP- or GTP-dependent ligation of succinate and CoA to form succinyl-CoA. The nature of the beta subunit determines the nucleotide specificity (By similarity).
PathwayCarbohydrate metabolism; tricarboxylic acid cycle.
Sequence CautionSequence=AAD17940.2; Type=Erroneous initiation; Evidence= ; Sequence=AAH00504.1; Type=Erroneous initiation; Evidence= ; Sequence=CAA92426.1; Type=Erroneous initiation; Evidence= ;
SimilarityBelongs to the succinate/malate CoA ligase alpha subunit family.
Subcellular LocationMitochondrion.
SubunitHeterodimer of an alpha and a beta subunit.