LMPD Database

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LMP004151

UniProt Annotations

Entry Information
Gene Namephosphatidylinositol transfer protein, membrane-associated 1
Protein EntryPITM1_MOUSE
UniProt IDO35954
SpeciesMouse
Comments
Comment typeDescription
Developmental StageDetected at low levels during fetal development up to day 15. Highly expressed at day 17.
FunctionRegulates RHOA activity, and plays a role in cytoskeleton remodeling. Necessary for normal completion of cytokinesis. Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Binds phosphatidyl inositol phosphates (in vitro). May catalyze the transfer of phosphatidylinositol and phosphatidylcholine between membranes (By similarity). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Golgi. Binds calcium ions (By similarity). {ECO:0000250}.
PtmPhosphorylated on multiple sites by CDK1 at the onset of mitosis. Phosphorylation facilitates dissociation from the Golgi complex and is required for interaction with PLK1 (By similarity). {ECO:0000250}.
PtmPhosphorylated on threonine residues upon treatment with oleic acid. {ECO:0000250}.
PtmPhosphorylated on tyrosine residues by PTK2B. {ECO:0000250}.
SimilarityBelongs to the PtdIns transfer protein family. PI transfer class IIA subfamily. {ECO:0000305}.
SimilarityContains 1 DDHD domain. {ECO:0000255|PROSITE- ProRule:PRU00378}.
Subcellular LocationCytoplasm {ECO:0000250}. Golgi apparatus, Golgi stack membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Lipid droplet {ECO:0000250}. Cleavage furrow {ECO:0000250}. Midbody {ECO:0000250}. Note=Peripheral membrane protein associated with Golgi stacks in interphase cells. A minor proportion is associated with the endoplasmic reticulum. Associated with lipid droplets. Dissociates from the Golgi early on in mitosis and localizes to the cleavage furrow and midbody during cytokinesis (By similarity). {ECO:0000250}.
SubunitInteracts with PTK2B via its C-terminus. Interacts with RHOA. Has higher affinity for the inactive, GDP-bound form of RHOA. The CDK1-phosphorylated form interacts with PLK1. Interacts with VAPB and PIK4CA (By similarity). {ECO:0000250}.
Tissue SpecificityDetected at high levels in brain, and at lower levels in lung, kidney, spleen and liver (at protein level). Ubiquitous. Highly expressed in embryonic retina and the central nervous system. {ECO:0000269|PubMed:9245688, ECO:0000269|PubMed:9680295}.