LMPD Database

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LMP004129

UniProt Annotations

Entry Information
Gene Namephospholipid scramblase 1
Protein EntryPLS1_MOUSE
UniProt IDQ9JJ00
SpeciesMouse
Comments
Comment typeDescription
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250};
DiseaseNote=Participates in a chromosomal translocation that produces MMTRA1A which is leukemogenic to syngenic SL mice and athymic nude mice.
DomainThe N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity. {ECO:0000250}.
FunctionMay mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. {ECO:0000269|PubMed:12010804}.
FunctionMay play a role in the antiviral response of interferon (IFN) by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes. May contribute to cytokine-regulated cell proliferation and differentiation. {ECO:0000269|PubMed:12010804}.
InductionUp-regulated by SCF/KITL and GCSF/CSF3. {ECO:0000269|PubMed:12010804}.
MiscellaneousKnockout newborn mice display a reduced granulocyte production. Hematopoietic precursor cell from knockout mice display defective colony formation and impaired differentiation to mature granulocytes as stimulated by SCF/KITL and GCSF/CSF3.
Sequence CautionSequence=BAA23663.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA23664.1; Type=Frameshift; Positions=92; Evidence={ECO:0000305};
SimilarityBelongs to the phospholipid scramblase family. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000250}; Single-pass type II membrane protein. Membrane; Lipid-anchor {ECO:0000250}; Cytoplasmic side. Nucleus {ECO:0000250}.
Tissue SpecificityHighly expressed in kidney, lung, liver and bone marrow, slightly in spleen, heart and macrophage.