LMPD Database

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LMP004105

UniProt Annotations

Entry Information
Gene Namecytochrome P450, family 51
Protein EntryCP51A_MOUSE
UniProt IDQ8K0C4
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityA 14-alpha-methylsteroid + 3 O(2) + 3 NADPH = a Delta(14)-steroid + formate + 3 NADP(+) + 4 H(2)O.
CofactorName=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
FunctionCatalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol. {ECO:0000250}.
PathwaySteroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 1/6.
Sequence CautionSequence=AAF73986.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000305}. Microsome membrane {ECO:0000305}.