LMPD Database

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LMP004097

UniProt Annotations

Entry Information
Gene Namenuclear receptor coactivator 2
Protein EntryNCOA2_HUMAN
UniProt IDQ15596
SpeciesHuman
Comments
Comment typeDescription
DiseaseNote=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N- terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.
DomainContains 2 C-terminal transcription activation domains (AD1 and AD2) that can function independently.
DomainContains four Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. The LXXLL motifs are essential for the association with nuclear receptors and are, at least in part, functionally redundant.
DomainThe LLXXLXXXL motif is involved in transcriptional coactivation and CREBBP/CBP binding.
FunctionTranscriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF- 2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. {ECO
InteractionP10275:AR; NbExp=2; IntAct=EBI-81236, EBI-608057; Q92841:DDX17; NbExp=2; IntAct=EBI-81236, EBI-746012; P03372:ESR1; NbExp=8; IntAct=EBI-81236, EBI-78473;
SimilarityBelongs to the SRC/p160 nuclear receptor coactivator family.
SimilarityContains 1 bHLH (basic helix-loop-helix) domain.
SimilarityContains 1 PAS (PER-ARNT-SIM) domain.
Subcellular LocationNucleus.
SubunitPresent in a complex containing NCOA3, IKKA, IKKB, IKBKG and CREBBP. Interacts (via C-terminus) with CREBBP. Interacts with ESR1, HIF1A, NCOA1, APEX, NR3C1, NR3C2, CARM1, RARA, and RXRA. Present in a complex containing CARM1 and EP300/P300. Interacts with CASP8AP2 and TTLL5/STAMP. Interacts with PSMB9 and DDX5. Interacts (via LXXLL 1, 2 and 3 motifs) with RORA and RORC (via AF-2 motif). Interacts with RWDD3. {ECO