LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP004092

UniProt Annotations

Entry Information
Gene Nameparaoxonase 3
Protein EntryPON3_MOUSE
UniProt IDQ62087
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityAn aryl dialkyl phosphate + H(2)O = dialkyl phosphate + an aryl alcohol. {ECO:0000269|PubMed:15963993}.
Catalytic ActivityAn N-acyl-L-homoserine lactone + H(2)O = an N- acyl-L-homoserine. {ECO:0000269|PubMed:15963993}.
Catalytic ActivityA phenyl acetate + H(2)O = a phenol + acetate. {ECO:0000269|PubMed:15963993}.
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; Note=Binds 2 calcium ions per subunit. {ECO:0000250};
FunctionHas low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents (By similarity). {ECO:0000250}.
PtmGlycosylated. {ECO:0000250}.
PtmThe signal sequence is not cleaved. {ECO:0000250}.
SimilarityBelongs to the paraoxonase family. {ECO:0000305}.
Subcellular LocationSecreted, extracellular space {ECO:0000250}.
SubunitHomodimer. {ECO:0000250}.