LMPD Database

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LMP003961

UniProt Annotations

Entry Information
Gene NameArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Protein EntryQ3UHD9_MOUSE
UniProt IDQ3UHD9
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3UHD9-1; Sequence=Displayed; Name=2; IsoId=Q3UHD9-2; Sequence=VSP_018542; Note=No experimental confirmation available.;
DomainArf-GAP domain interacts with G domain and may regulate its GTPase activity.
DomainG domain binds GTP and has GTPase activity.
DomainPH domain binds phospholipids and is required for nuclear targeting.
Enzyme RegulationGAP activity is stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and, to a lesser extent, by phosphatidylinositol 3,4,5-trisphosphate (PIP3). Phosphatidic acid potentiates PIP2 stimulation (By similarity). {ECO:0000250}.
FunctionGTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. Aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase (By similarity). {ECO:0000250}.
SimilarityBelongs to the centaurin gamma-like family. {ECO:0000305}.
SimilarityContains 1 Arf-GAP domain. {ECO:0000255|PROSITE- ProRule:PRU00288}.
SimilarityContains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
SimilarityContains 2 ANK repeats. {ECO:0000255|PROSITE- ProRule:PRU00023}.
Subcellular LocationCytoplasm. Nucleus {ECO:0000250}.
SubunitInteracts with EPB41L1, PLCG1, NF2, HOMER1 and HOMER2. {ECO:0000250}.