LMPD Database

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LMP003954

UniProt Annotations

Entry Information
Gene Nameprotein arginine methyltransferase 3
Protein EntryQ8WUV3_HUMAN
UniProt IDQ8WUV3
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O60678-1; Sequence=Displayed; Name=2; IsoId=O60678-2; Sequence=VSP_040330; Note=No experimental confirmation available.;
DomainThe zinc-finger is responsible for substrate specificity.
Enzyme RegulationInhibited by N-ethylmaleimide and high concentrations of zinc chloride.
FunctionMethylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins.
InteractionQ14524:SCN5A; NbExp=2; IntAct=EBI-2809009, EBI-726858;
SimilarityBelongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N- methyltransferase family.
SimilarityContains 1 C2H2-type zinc finger.
SimilarityContains 1 SAM-dependent MTase PRMT-type domain.
Subcellular LocationCytoplasm.
SubunitMonomer or homodimer (By similarity). Interacts with EPB41L3; this inhibits methylation of target proteins. Interacts with the 40S ribosomal protein RPS2. {ECO