| Comment type | Description |
|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q62028-1; Sequence=Displayed; Name=2; IsoId=Q62028-2; Sequence=VSP_029495, VSP_029496; Note=No experimental confirmation available.; |
| Disruption Phenotype | Mice are viable, fertile and without evident histopathological abnormalities. After challenge with bacterial lipopolysaccharide (LPS), they exhibit longer survival than wild- type mice. They are also resistant to lethal effects of exogenous sPLA2-IB/PLA2G1B after sensitization with sublethal dose of LPS, suggesting a potential role in the progression of endotoxic shock. {ECO:0000269|PubMed:9407054}. |
| Domain | C-type lectin domains 3-5 mediate the interaction with phospholipase PLA2G1B. {ECO:0000269|PubMed:7925459}. |
| Domain | The endocytosis signal probably mediates endocytosis via clathrin-coated pits. {ECO:0000250}. |
| Function | Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipases sPLA2-IB/PLA2G1B, sPLA2-X/PLA2G10 and, with lower affinity, sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B and sPLA2-X/PLA2G10. {ECO:0000269|PubMed:10922494, ECO:0000269|PubMed:10946309, ECO:0000269|PubMed:11019817, ECO:0000269|PubMed:11481246, ECO:0000269|PubMed:11741598, ECO:0000269|PubMed:11830583, ECO:0000269|PubMed:12225974, ECO:0000269|PubMed:16815622, ECO:0000269|PubMed:17279628, ECO:0000269|PubMed:7925459, ECO:0000269|PubMed:9407054}. |
| Induction | Following exposure to endotoxin (at protein level). {ECO:0000269|PubMed:10864436}. |
| Ptm | The secretory phospholipase A2 receptor form may be produced by the action of metalloproteinases. It contains all extracellular domains and only lacks transmembrane and cytosolic regions. It is however unclear whether this form is produced by proteolytic cleavage as suggested by some experiments reported by PubMed:11830583, or by alternative splicing. |
| Sequence Caution | Sequence=CAM22305.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAM23630.1; Type=Erroneous initiation; Evidence={ECO:0000305}; |
| Similarity | Contains 1 fibronectin type-II domain. {ECO:0000255|PROSITE-ProRule:PRU00479}. |
| Similarity | Contains 1 ricin B-type lectin domain. {ECO:0000255|PROSITE-ProRule:PRU00174}. |
| Similarity | Contains 8 C-type lectin domains. {ECO:0000255|PROSITE-ProRule:PRU00040}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:11830583}; Single-pass type I membrane protein {ECO:0000269|PubMed:11830583}. |
| Subcellular Location | Soluble secretory phospholipase A2 receptor: Secreted. |
| Tissue Specificity | Widely expressed. Present in type II alveolar epithelial cells and a subset of splenic lymphocytes. Present at the surface of polymorphonuclear neutrophils (at protein level). {ECO:0000269|PubMed:10864436, ECO:0000269|PubMed:12225974, ECO:0000269|PubMed:7925459}. |
| Web Resource | Name=Functional Glycomics Gateway - Glycan Binding; Note=Phospholipase A2 receptor; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Ctlect_356"; |