LMPD Database

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LMP003902

UniProt Annotations

Entry Information
Gene Nameglucocorticoid modulatory element binding protein 2
Protein EntryGMEB2_HUMAN
UniProt IDQ9UKD1
SpeciesHuman
Comments
Comment typeDescription
FunctionTrans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses.
Sequence CautionSequence=BAA86583.1; Type=Erroneous initiation; Evidence= ;
SimilarityContains 1 SAND domain. {ECO
Subcellular LocationNucleus. Cytoplasm. Note=May be also cytoplasmic.
SubunitHomodimer, and heterodimer of GMEB1 and GMEB2. GMEB1 and GMEB2 form the parvovirus initiator complex (PIF). Interacts with the glucocorticoid receptor (NR3C1). May interact with CREB- binding protein (CBP).
Tissue SpecificityExpressed in peripheral blood lymphocytes and fetal liver. Expressed preferentially in reproductive and/or developmentally important cells, such as testis, placenta, bone marrow and fetal tissues.