LMPD Database

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LMP003839

UniProt Annotations

Entry Information
Gene Namephosphoinositide-3-kinase adaptor protein 1
Protein EntryBCAP_HUMAN
UniProt IDQ6ZUJ8
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; Synonyms=BCAP-L; IsoId=Q6ZUJ8-1; Sequence=Displayed; Name=2; Synonyms=BCAP-S; IsoId=Q6ZUJ8-2; Sequence=VSP_034238; Name=3; IsoId=Q6ZUJ8-3; Sequence=VSP_034239, VSP_034240;
DomainThe DBB domain is required for dimerization.
FunctionSignaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL.
PtmConstitutively phosphorylated. Phosphorylated on tyrosine residues in C-terminal region by ABL1. Phosphorylated on tyrosine residues within the YXXM motifs by BTK and SYK (By similarity). Isoform 1 and isoform 2 are phosphorylated on tyrosine residues, most likely within the YXXM motifs, via CD19 activation (By similarity). Toll-like receptor activation induces appearance of a phosphorylated form associated with membranes (By similarity).
SimilarityContains 1 DBB domain. {ECO
Subcellular LocationCytoplasm . Cell membrane {ECO
SubunitHomooligomer (By similarity). Interacts (phosphorylated on tyrosine residues within YXXM motifs) with PIK3R1 (via SH2 domain); required for BCR- and TLR-mediated activation of phosphoinositide 3-kinase. Interacts (via polyproline C-terminal region) with ABI1 (via SH3 domain); the interaction promotes phosphorylation of PIK3AP1 by ABL1. May interact with MYD88 and TIRAP (By similarity).
Tissue SpecificityExpressed in natural killer (NK) cells.