LMPD Database

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LMP003838

UniProt Annotations

Entry Information
Gene Namecytochrome P450, family 4, subfamily f, polypeptide 18
Protein EntryQ99N16_MOUSE
UniProt IDQ99N16
SpeciesMouse
Comments
Comment typeDescription
Catalytic Activity(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa- 6,8,10,14-tetraenoate + NADPH + O(2) = (6Z,8E,10E,14Z)-(5S,12R)- 5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + NADP(+) + H(2)O.
CofactorName=heme; Xref=ChEBI:CHEBI:30413; Evidence= ;
Enzyme RegulationInhibited by carbon monoxide (CO).
FunctionCytochromes P450 are a group of heme-thiolate monooxygenases. This enzyme requires molecular oxygen and NADPH for the omega-hydroxylation of LTB4, a potent chemoattractant for polymorphonuclear leukocytes. {ECO:0000250|UniProtKB:Q08477, ECO:0000269|PubMed:16380383}.
InductionUp-regulated in myeloid dendritic cells upon induction with LPS in vitro. Down-regulated upon migration of induced cells to the lymph node.
PathwayLipid metabolism; leukotriene B4 degradation.
SimilarityBelongs to the cytochrome P450 family.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein . Microsome membrane ; Single-pass membrane protein .
Tissue SpecificityHighest level in polymorphonuclear leukocytes and dendritic cells. Detectable in lymph nodes, spleen, bone marrow and peripheral blood. Highly expressed in ovary. Very low level in liver, kidney, and smooth muscle.