LMPD Database

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LMP003828

UniProt Annotations

Entry Information
Gene Namecalmodulin 1
Protein EntryCALM_MOUSE
UniProt IDP62204
SpeciesMouse
Comments
Comment typeDescription
FunctionCalmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). {ECO:0000250}.
InteractionQ7TSH4:Ccp110; NbExp=4; IntAct=EBI-397460, EBI-646843; Q08460:Kcnma1; NbExp=4; IntAct=EBI-397460, EBI-1633915; O14829:PPEF1 (xeno); NbExp=2; IntAct=EBI-397460, EBI-2931238; O14830:PPEF2 (xeno); NbExp=2; IntAct=EBI-397460, EBI-2931306;
MiscellaneousThis protein has four functional calcium-binding sites.
PtmPhosphorylation results in a decreased activity. {ECO:0000250}.
PtmUbiquitination results in a strongly decreased activity. {ECO:0000250}.
SimilarityBelongs to the calmodulin family. {ECO:0000305}.
SimilarityContains 4 EF-hand domains. {ECO:0000255|PROSITE- ProRule:PRU00448}.
Subcellular LocationCytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules. {ECO:0000250}.
SubunitInteracts with CEP97, CCP110, MYO1C, TTN/titin and SRY. Interacts with MYO10. Interacts with RRAD (By similarity). Interacts with USP6; the interaction is calcium dependent (By similarity). Interacts with CDK5RAP2. Interacts with SCN5A (By similarity). Interacts with FCHO1. Interacts with MIP in a 1:2 stoichiometry; the interaction with the cytoplasmic domains from two MIP subunits promotes MIP water channel closure. Interacts with ORAI1; this may play a role in the regulation of ORAI1- mediated calcium transport (By similarity). Interacts with RYR1 and RYR2. Interacts with MYO5A. {ECO:0000250, ECO:0000269|PubMed:17151196, ECO:0000269|PubMed:18650434}.