LMPD Database

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LMP003827

UniProt Annotations

Entry Information
Gene Namediacylglycerol lipase, alpha
Protein EntryDGLA_HUMAN
UniProt IDQ9Y4D2
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=154.7 uM for diacylglycerol ; Vmax=33.3 nmol/min/mg enzyme ; pH dependence: Optimum pH is 7.0. ;
CofactorName=Ca(2+); Xref=ChEBI
DiseaseSpinocerebellar ataxia 20 (SCA20) [MIM
Enzyme RegulationInhibited by p-hydroxy-mercuri-benzoate and HgCl(2), but not to PMSF. Also inhibited by RHC80267, a drug that blocks 2-AG formation.
FunctionCatalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.
Sequence CautionSequence=BAA31634.2; Type=Erroneous initiation; Evidence= ;
SimilarityBelongs to the AB hydrolase superfamily. Lipase family.
Subcellular LocationCell membrane; Multi-pass membrane protein.
Tissue SpecificityHighly expressed in brain and pancreas.