LMPD Database

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LMP003789

UniProt Annotations

Entry Information
Gene Nameglucocorticoid modulatory element binding protein 2
Protein EntryGMEB2_MOUSE
UniProt IDP58929
SpeciesMouse
Comments
Comment typeDescription
FunctionTrans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter (By similarity). {ECO:0000250}.
SimilarityContains 1 SAND domain. {ECO:0000255|PROSITE- ProRule:PRU00185}.
Subcellular LocationNucleus {ECO:0000255|PROSITE- ProRule:PRU00185}. Cytoplasm {ECO:0000250}. Note=May be also cytoplasmic. {ECO:0000250}.
SubunitHomodimer, and heterodimer of GMEB1 and GMEB2. Interacts with the glucocorticoid receptor (NR3C1). May interact with CREB- binding protein (CBP) (By similarity). {ECO:0000250}.