LMPD Database

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LMP003713

UniProt Annotations

Entry Information
Gene Namediacylglycerol lipase, beta
Protein EntryDGLB_HUMAN
UniProt IDQ8NCG7
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8NCG7-1; Sequence=Displayed; Name=2; IsoId=Q8NCG7-2; Sequence=VSP_020245; Note=No experimental confirmation available.; Name=3; IsoId=Q8NCG7-3; Sequence=VSP_020246, VSP_020247; Note=No experimental confirmation available.; Name=4; IsoId=Q8NCG7-4; Sequence=VSP_043309; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=74.1 uM for diacylglycerol ; Vmax=3.45 nmol/min/mg enzyme ; pH dependence: Optimum pH is 7.0. ;
CofactorName=Ca(2+); Xref=ChEBI
Enzyme RegulationInhibited by p-hydroxy-mercuri-benzoate and HgCl(2), but not to PMSF. Also inhibited by RHC80267, a drug that blocks 2-AG formation.
FunctionCatalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.
Sequence CautionSequence=BAB85017.1; Type=Erroneous initiation; Evidence= ;
SimilarityBelongs to the AB hydrolase superfamily. Lipase family.
Subcellular LocationCell membrane ; Multi-pass membrane protein .