LMPD Database


UniProt Annotations

Entry Information
Gene Nameacid phosphatase 6, lysophosphatidic
Protein EntryPPA6_HUMAN
UniProt IDQ9NPH0
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NPH0-1; Sequence=Displayed; Name=2; IsoId=Q9NPH0-2; Sequence=VSP_014121, VSP_014122; Note=No experimental confirmation available.;
Catalytic ActivityA phosphate monoester + H(2)O = an alcohol + phosphate.
CautionIt is uncertain whether Met-1 or Met-8 is the initiator.
CautionWas originally reported to be located in the mitochondrion, but the evidence seems to be weak and contradictory with the presence of a cleaved signal sequence.
FunctionHydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid. {ECO
InductionInduced with the differentiation from myoblast to myotube.
Sequence CautionSequence=BAA89311.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ; Sequence=BAD92485.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence= ;
SimilarityBelongs to the histidine acid phosphatase family.
Subcellular LocationMitochondrion .
Tissue SpecificityHighly expressed in kidney, heart, small intestine, muscle, liver, prostate, testis, ovary and weakly expressed in thymus and colon. {ECO