LMPD Database

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LMP003674

UniProt Annotations

Entry Information
Gene Nameubiquitin interaction motif containing 1
Protein EntryUIMC1_HUMAN
UniProt IDQ96RL1
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q96RL1-1; Sequence=Displayed; Name=2; IsoId=Q96RL1-2; Sequence=VSP_012935; Name=3; Synonyms=XHRIP110; IsoId=Q96RL1-3; Sequence=VSP_012932; Name=4; Synonyms=X2HRIP110; IsoId=Q96RL1-4; Sequence=VSP_012933, VSP_012934; Name=5; IsoId=Q96RL1-5; Sequence=VSP_037264, VSP_037265; Note=No experimental confirmation available.;
DomainThe Abraxas-interacting region (AIR) mediates the interaction with FAM175A/Abraxas.
DomainThe UIM-linker region between the 2 UIM repeats determines the selectivity for 'Lys-63'-linked ubiquitin. The length of the linker is important. The linker reduces the flexibility between the UIM repeats and promotes high-affinity and linkage-selective interactions.
FunctionUbiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {ECO
InteractionP54132:BLM; NbExp=2; IntAct=EBI-725300, EBI-621372; P38398:BRCA1; NbExp=9; IntAct=EBI-725300, EBI-349905; Q6UWZ7:FAM175A; NbExp=9; IntAct=EBI-725300, EBI-1263451;
PtmPhosphorylated upon DNA damage by ATM or ATR. {ECO
PtmSumoylated.
Sequence CautionSequence=AAH06078.1; Type=Erroneous termination; Positions=386; Note=Translated as Glu.; Evidence= ;
SimilarityBelongs to the RAP80 family.
SimilarityContains 2 UIM (ubiquitin-interacting motif) repeats.
Subcellular LocationNucleus {ECO
SubunitInteracts with TSP57 (By similarity). Component of the BRCA1-A complex, at least composed of the BRCA1, BARD1, UIMC1/RAP80, FAM175A/Abraxas, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with FAM175A/Abraxas. Interacts with ESR1, NR6A1 and UBE2I. {ECO
Tissue SpecificityExpressed in testis, ovary, thymus and heart. Expressed in germ cells of the testis.