LMPD Database

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LMP003654

UniProt Annotations

Entry Information
Gene Nameprotein arginine N-methyltransferase 8
Protein EntryANM8_MOUSE
UniProt IDQ6PAK3
SpeciesMouse
Comments
Comment typeDescription
DomainThe N-terminal region (1-60) inhibits the enzymatic activity. {ECO:0000250}.
DomainThe SH3-binding motifs mediate the interaction with SH3 domain-containing proteins such as PRMT2 and FYN, possibly leading to displace the N-terminal domain and activate the protein. {ECO:0000250}.
FunctionMembrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA). Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS (By similarity). {ECO:0000250}.
Sequence CautionSequence=AAH60250.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N- methyltransferase family. PRMT8 subfamily. {ECO:0000255|PROSITE- ProRule:PRU01015}.
SimilarityContains 1 SAM-dependent MTase PRMT-type domain. {ECO:0000255|PROSITE-ProRule:PRU01015}.
Subcellular LocationCell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
SubunitHomodimers and heterodimers with PRMT1 or PRMT2, recruiting PRMT1 to the cell membrane. Interacts with PRMT2 and FYN (via the SH3 domain). Interacts with EWS; independently of EWS methylation status (By similarity). {ECO:0000250}.
Tissue SpecificityBrain-specific. Only expressed in neurons, especially in the somatosensory and limbic systems, and a part of motor system. Highly expressed in all of the regions related to general somatosensory system. Expressed in most of the relay nuclei intervening the special somatosensory system, such as the auditory, visual and vestibular systems. Also present in forebrain limbic areas and thalamic nuclei relevant to limbic areas and in areas related to the motor system, such as the caudate putamen, Purkinje cells, inferior olivary nucleus and cerebellar nuclei. {ECO:0000269|PubMed:17512914}.