LMPD Database

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LMP003598

UniProt Annotations

Entry Information
Gene Namezinc metallopeptidase STE24
Protein EntryFACE1_HUMAN
UniProt IDO75844
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityThe peptide bond hydrolyzed can be designated -C-|-A-A-X in which C is an S-isoprenylated cysteine residue, A is usually aliphatic and X is the C-terminal residue of the substrate protein, and may be any of several amino acids.
CofactorName=Zn(2+); Xref=ChEBI
DiseaseLethal tight skin contracture syndrome (LTSCS) [MIM
DiseaseMandibuloacral dysplasia with type B lipodystrophy (MADB) [MIM
DomainThe metalloprotease domain is constituted by the two C- terminal nuclear regions.
FunctionProteolytically removes the C-terminal three residues of farnesylated proteins. Acts on lamin A/C.
SimilarityBelongs to the peptidase M48A family.
Subcellular LocationEndoplasmic reticulum membrane ; Multi-pass membrane protein . Nucleus inner membrane ; Multi-pass membrane protein .
Tissue SpecificityWidely expressed. High levels in kidney, prostate, testis and ovary.